The right-back arrived from Middlesbrough during the last transfer window following an impressive season on loan at Nottingham Forest which cost Spurs £13m, reports the Express.
Since his arrival, the 22-year-old has found his match time severely limited, coming on for just one minute in three Premier League games.
Spence is behind Emerson Royal, Matt Doherty and Ivan Perisic in the pecking order for the right wing-back position and as a result, the Englishman could be shipped out on loan to get some much-needed game time for his development, reports the Times.
A loan move could be of benefit to Spence if Conte does not trust him at Spurs as it would not be beneficial for the right-back to sit on the bench all season.
The 22-year-old needs to continue his development and that can only be done by playing football and he looks no closer to pushing his way into the Tottenham team.
It is unclear if the loan move would be to another Premier League club or to take a step back down to the Championship given his success there last season but it should be the former, as it would be the best way for the defender to get used to the league.